Protein Modification Reagents
Medchemexpress LLC Biotin-PEG4-Amide-C6-Azide | 1006592-62-6 | 99.1% | C27H49N7O7S | 500 MG
Biotin-PEG4-Amide-C6-Azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an Azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with Alkyne groups
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups
Medchemexpress LLC Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane | 1421933-29-0 | 97.0% | C36H66N4O14 | 50 MG
Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Azide group for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Alkyne groups. It can also engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups.
- PROTAC linker
- Click chemistry reagent
- Contains an azide group for CuAAc reaction
- Can undergo SPAAC reactions with DBCO or BCN groups
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Dspe-peg-maleimide, MW 5000 | 99.8% | 100 MG
Dspe-peg-maleimide, MW 5000, is a linker lipid containing DSPE phospholipid and Maleimide. This compound is used in the synthesis of various liposomes and as a linker in immunoliposome synthesis for laboratory applications.
- Contains DSPE phospholipid and Maleimide.
- Utilized in liposome synthesis (HELDC, sterically stabilized, and immunoliposomes).
- Can be coupled with thiol-p5314-29 peptide for immunoliposome synthesis.
- Sterically stabilized liposomes can be coupled with thiolated monoclonal antibody OX26 (OX26-SH).
- HELDC liposomes with 3% DSPE-PEG-maleimide maintain particle size stability over two weeks (avg. 120 nm diameter).
- Molecular weight: 5000 (average).
- Appears as a white to off-white solid.
- For research use only.
Cayman Chemical PEG 2000-dPE 10mg
A PEGylated form of DSPE; has been used in the generation of micelles and in combination with other lipids in the formation of liposomes; liposomes containing DSPE-mPEG(2000) and encapsulating doxorubicin and quercetin reduce tumor growth in an MCF-7/adr multidrug-resistant breast cancer mouse xenograft model
Worthington Biochemical Corporation PAPAIN DISSOCIATION SYS 3BX
Complete kit as described for product Code: PDS, but without the Earle's Balanced Salt Solution (EBSS).
Medchemexpress LLC Mal-amido-PEG24-acid | 2171095-70-6 | 98.5% | C58H108N2O29 | 100 MG
Mal-amido-PEG24-acid is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. These molecules are engineered to contain two distinct ligands connected by a linker: one targets an E3 ubiquitin ligase, and the other binds to a specific target protein. This mechanism allows PROTACs to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- PEG-based linker for PROTAC synthesis
- Facilitates targeted protein degradation
- Utilizes the ubiquitin-proteasome system
Medchemexpress LLC Biotin-PEG4-amine | 663171-32-2 | MFCD26142992 | 98.0% | C20H38N4O6S | 50 MG
Biotin-PEG4-amine is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Biotin-labeled for specific applications
- PEG-based for improved solubility and reduced immunogenicity
- Functions as a PROTAC linker
- Facilitates targeted protein degradation
Medchemexpress LLC Dspe-peg-maleimide, mw 5000 | 99.84% | 500 MG
DSPE-PEG-Maleimide, MW 5000, is a linker lipid composed of DSPE phospholipid and Maleimide. It is utilized in the synthesis of various liposomes, including HELDC liposomes, sterically stabilized liposomes, and immunoliposomes. It is for research use only.
- Appearance: Solid
- Color: White to off-white
- Molecular weight: 5000 (average)
- Solubility (In vitro): Soluble in DMSO at 50 mg/mL (requires ultrasonic and warming to 60°C; hygroscopic DMSO significantly impacts solubility)
- Functions as a linker lipid in immunoliposome synthesis
- Can be coupled with thiol-p5314-29 peptide
- Sterically stabilized liposomes containing this product can be coupled with thiolated monoclonal antibody OX26 (OX26-SH)
- HELDC liposomes prepared with 3% of this product show stability in particle size over two weeks, maintaining an average diameter of 120 nm
Medchemexpress LLC Azido-PEG4-Amido-Tris | 1398044-55-7 | 96.4% | C15H30N4O8 | 100 MG
Azido-PEG4-Amido-Tris is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group that can participate in copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules possessing Alkyne groups. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs involve two distinct ligands connected by a linker, one for an E3 ubiquitin ligase and the other for the target protein, enabling the selective degradation of target proteins via the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Click chemistry reagent
- Contains an Azide group for CuAAc reaction
- Can undergo SPAAC reactions
- Used in the synthesis of PROTACs
Medchemexpress LLC Bcn-peg3-biotin | 1263166-92-2 | 95.0% | 594.76 | C29H46N4O7S | 5 MG
BCN-PEG3-Biotin is a biotinylated, non-cleavable PEG3 linker containing a bicyclononyne (BCN) group used for copper-free click chemistry and the synthesis of antibody-drug conjugates and bioconjugation workflows.
- Non-cleavable PEG3 linker enabling spacer functionality and biotin capture.
- BCN group for strain-promoted alkyne-azide cycloaddition (SPAAC) with azide partners.
- Purity 95.0% and molecular weight 594.76.
- Soluble in DMSO at 100 mg/mL; ultrasonic assistance recommended.
- Powder stable at -20°C for up to 3 years; in solvent store at -80°C for long-term stability.
Medchemexpress LLC HY-112496 100mg Medchemexpress, Cl-C6-PEG4-O-CH2COOH CAS:1799506-30-1 Purity:>98%
Medchemexpress, HY-112496 100mg Cl-C6-PEG4-O-CH2COOH CAS:1799506-30-1 Cl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) is a PEG-based PROTAC linker can be used in the synthesis of chloroalkane-containing PROTACs (HaloPROTACs). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.